Bleomycin sclerotherapy in congenital lymphatic and vascular malformations of head and neck.
نویسندگان
چکیده
Bleomycin is an established antineoplastic drug, but recently some attempts were made to inject it locally as a sclerosing agent in cases of congenital lymphatic malformations. We present the outcome of this treatment modality tried on 10 paediatric cases of whom 9 had such malformation in the cervical region and one in the parotid region. Seven of these cases had congenital lymphatic malformation while three had haemodynamically less active congenital vascular malformation. All these children were subjected to percutaneous intralesional administration of bleomycin. The size of swelling reduced by 50% or more in seven patients out of which three showed complete or near complete response. There were no major deleterious side effects.
منابع مشابه
Bleomycin sclerotherapy for lymphatic malformation after unsuccessful surgical excision: case report Scleroterapia con bleomicina per malformazioni linfatiche dopo fallimento dell’escissione chirurgica: caso clinico
lymphatic malformations (lMs) are benign cystic masses resulting from the abnormal development of lymphatic channels. lymphatic malformations occur primarily in the head and neck region. Surgical excision of lymphatic malformation is followed by high rate of recurrence and a high risk of complications. Bleomycin is an established antineoplastic drug. it can be used as a sclerosing agent in vasc...
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OBJECTIVES/HYPOTHESIS To describe a multidisciplinary approach to the treatment of airway vascular malformations (venous or lymphatic) with direct suspension rigid laryngoscopy and direct puncture transmucosal bleomycin sclerotherapy injected under road-mapping fluoroscopic monitoring, supplemented by Dyna-computed tomography utilization. STUDY DESIGN Case series. METHODS We performed a ret...
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BACKGROUND Venous malformations (VMs) are common vascular anomalies; 40% are found in the head and neck. Percutaneous sclerotherapy is 1 treatment of choice. METHODS In all, 17 patients with facial VMs were treated by percutaneous sclerotherapy using alcohol and individually matched to lesions treated with bleomycin. Treatment details and outcomes were compared. The average numbers of session...
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Lymphatic malformations (LM) are benign congenital malformations of the lymphatic system. They are frequently seen in the neck and sometimes can be life-threatening due to compression to the airway. Treatment modalities are widespread including surgical excision, radiotherapy, laser therapy, and application of intralesional sclerosing agents. We report the successful treatment of cervical LM in...
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BACKGROUND AND PURPOSE Venous malformations are the most common of all vascular anomalies, 40% of which are found in the head and neck. We discuss results of percutaneous sclerotherapy using bleomycin for facial VMs by using subjective clinical assessment and objective changes on MR imaging. MATERIALS AND METHODS Thirty-seven patients with facial VMs were treated by percutaneous sclerotherapy...
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ورودعنوان ژورنال:
- International journal of pediatric otorhinolaryngology
دوره 69 1 شماره
صفحات -
تاریخ انتشار 2005